By Isabelle Mus-Veteau Ph.D. (auth.), Isabelle Mus-Veteau (eds.)
Membrane proteins play a key function in different pathologies akin to melanoma, cystic fibrosis, epilepsy, hyperinsulinism, and Alzheimer’s illness, but experiences on those and different problems are hampered through an absence of data concerning the proteins concerned. In Heterologous Expression of Membrane Proteins: equipment and Protocols, professional researchers offer an outline of the various heterologous expression platforms on hand to supply those proteins for structural research, supporting us to appreciate how those proteins functionality, and also, how their services may be changed via drug therapy. Chapters learn membrane protein solubilization, purification, and instability in answer, and examine the options that helped to figure out the constitution of the 1st heterologously expressed mammalian membrane proteins. Composed within the hugely winning Methods in Molecular Biology™ sequence structure, each one bankruptcy includes a short advent, step by step tools, an inventory of beneficial fabrics, and a Notes part which stocks tips about troubleshooting and warding off identified pitfalls.
Far-reaching and leading edge, Heterologous Expression of Membrane Proteins: tools and Protocols, is an important consultant for amateur and skilled researchers alike, delivering specific equipment for latest expression structures along state-of-the-art concepts for destiny use within the box.
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